And top of the bill will be saxophonist Tommy Smith and the Scottish National Jazz Orchestra who will play at Hamilton Town House to mark the opening of the three-day event.
The concert will feature the music of Joe Williams and the incredible Ray Charles, while talented pianist Brian Kellock and Tam White, one of Scotland’s leading blues singers, will bring some added class to the proceedings
While the SNJO's performance will be the biggest draw of the night, four other groups will perform on Friday.
From 4.30pm until 7.30pm, the June Love Duo will dim the lights in Bar West.
At 8pm, jazz fans can choose from the Moodswings (The Villa Hotel), the Clyde Rhythm Group (ML3 Bar +) and Cadenza (Di Maggio’s).
Musicians are then invited to take along their instruments to a late-night jamming session at the ML3+ Bar between 11pm and 1am.
On Saturday, September 6, jazz guitar duo Duncan McCallum and Dougie Harrison start things early between 2pm and 5pm at Bar Strada before the Alan Gilbert Duo (Clydesdale Hotel), the Rev Doc and the Congregation (Bay Horse), the Clyde Rhythm Group (The George Bar) and The Matt Adams Collective (Tap Room) will take fans into the night.
As if that isn’t enough, The George Bar will also hold a late night jamming session between 11pm till 1am.
The festival comes to a close on Sunday at the Stonehouse pub between 4pm and 7pm with Baby Isaac before the Avon Jazz Group, with a special guest, appear at The George Bar between 8pm and 11pm.
All the but Town House event at the Hamilton Jazz and Blues Festival are free.
Programme:Friday, September 5:
Hamilton Town House, 7.30pm - Tommy Smith.
Bar West, 4.30pm till 7.30pm - June Love Duo.
The Villa Hotel, 8pm till 11pm - Moodswings.
ML3 Bar +, 8pm till 11pm - Clyde Rhythm Group.
Di Maggio’s, 8pm till 11pm - Cadenza
Saturday, September 6.
Bar Strada, 2pm till 5pm - Jazz Guitar Duo Duncan McCallum and Dougie Harrison.
Clydesdale Hotel, 8pm till 11pm - Alan Gilbert Duo.
Bay Horse, 8pm till 11pm - Rev. Doc and the Congregation.
The George Bar, 8pm till 11pm - Clyde Rhythm Group.
Tap Room, 8pm till 11pm - The Matt Adams.
Sunday, September 7: Stonehouse, 4pm till 7pm - Baby Isaac.
The George Bar, 8pm till 11pm - Avon Jazz Group and guest.
Late Night Jam Sessions: All musicians are welcome to bring their own instruments and join in the following:
Friday, September 5: ML3 Bar+, 11pm till 1am. Saturday, September 6: The George Bar, 11pm till 1am.